Our Publications

Marway, M. K.; Bhagentsang, D.; Venugopal, C.; Singh, S. K.; Wylie, R. G.; Zhang, B. Crossing Barriers: In Vitro Cancer Model for Studying Monocyte Migration across Endothelial Barriers. ACS Biomaterials Science & Engineering 2025, 11 (8), 5038-5050.

Rajasekar, S.; Chakravarty, A.; Jozani, K. A.; Truong, B.; Hendrickson, M.; Attia, A.; Sabouny, M.; Basatskaya, A.; Clotet-Freixas, S.; Ludlow, M.; Sotra, A.; Lin, D. S. Y.; Zhang, F.; Zhang, B. A High-Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury. Advanced Materials Technologies 2025, 10 (19).

Singer, R.; Milad, N.; Ball, E.; Nguyen, J. P.; Cao, Q.; Selvaganapathy, R.; Zhang, B.; Dabaghi, M.; Satia, I.; Hirota, J. A. Open-source, three-dimensionally printed manifolds for exposure studies using human airway epithelial cells. ERJ Open Research 2025, 11 (3), 00703-2024.

Kouthouridis, S.; Saha, P.; Ludlow, M.; Truong, B. Y. N.; Zhang, B. Late-stage placental barrier model for transport studies of prescription drugs during pregnancy. Lab on a Chip 2025, 25 (13), 3168-3184.

Zhang, F.; Jozani, K. A.; Chakravarty, A.; Lin, D.; Hollinger, A.; Rajasekar, S.; Zhang, B. Immune‐Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue‐Specific Macrophage Recruitment. Advanced Healthcare Materials 2025, 14 (9).

Liu, J.; You, Z.; Li, X.; Zhang, B.; Sun, J.; Wang, Z. Haversian bone mimicking scaffold with built-in vasculature for bone tissue engineering. Chemical Engineering Journal 2025, 506, 160023.

Cariba, S.; Srivastava, A.; Bronsema, K.; Kouthouridis, S.; Zhang, B.; Payne, S. L. Innervated Coculture Device to Model Peripheral Nerve-Mediated Fibroblast Activation. ACS Biomaterials Science & Engineering 2024, 10 (12), 7566-7576.

Wu, Q.; Rafatian, N.; Wagner, K. T.; Blamer, J.; Smith, J.; Okhovatian, S.; Aggarwal, P.; Wang, E. Y.; Banerjee, A.; Zhao, Y.; Nash, T. R.; Lu, R. X. Z.; Portillo-Esquivel, L. E.; Li, C. Y.; Kuzmanov, U.; Mandla, S.; Virlee, E.; Landau, S.; Lai, B. F.; Gramolini, A. O.; Liu, C.; Fleischer, S.; Veres, T.; Vunjak-Novakovic, G.; Zhang, B.; Mossman, K.; Broeckel, U.; Radisic, M. SARS-CoV-2 pathogenesis in an angiotensin II-induced heart-on-a-chip disease model and extracellular vesicle screening. PNAS 2024, 121 (28).

Zhao, Y.; Landau, S.; Okhovatian, S.; Liu, C.; Lu, R. X. Z.; Lai, B. F. L.; Wu, Q.; Kieda, J.; Cheung, K.; Rajasekar, S.; Jozani, K. A.; Zhang, B.; Radisic, M. Integrating organoids and organ-on-a-chip devices. Nature Reviews Bioengineering 2024, 2, 588-608.

Rjaibi, S. T.; Jacques, E.; Ni, J.; Xu, B.; Kouthouridis, S.; Sitolle, J.; Lad, H.; Gulati, N.; Li, N. T.; Ahn, H.; Ginsberg, H. J.; Zhang, B.; Le Grand, F.; Gilbert, P. M.; McGuigan, A. P. A Cryopreservation Strategy for Myoblast Storage in Paper‐Based Scaffolds for Inter‐Laboratory Studies of Skeletal Muscle Health. Advanced Materials Interfaces 2024, 11 (33).

Clotet-Freixas, S.; Zaslaver, O.; Kotlyar, M.; Pastrello, C.; Quaile, A. T.; McEvoy, C. M.; Saha, A. D.; Farkona, S.; Boshart, A.; Zorcic, K.; Neupane, S.; Manion, K.; Allen, M.; Chan, M.; Chen, X.; Arnold, A. P.; Sekula, P.; Steinbrenner, I.; Köttgen, A.; Dart, A. B.; Wicklow, B.; McGavock, J. M.; Blydt-Hansen, T. D.; Barrios, C.; Riera, M.; Soler, M. J.; Isenbrandt, A.; Lamontagne-Proulx, J.; Pradeloux, S.; Coulombe, K.; Soulet, D.; Rajasekar, S.; Zhang, B.; John, R.; Mehrotra, A.; Gehring, A.; Puhka, M.; Jurisica, I.; Woo, M.; Scholey, J. W.; Röst, H.; Konvalinka, A. Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease. Science Translational Medicine 2024, 16 (737), eabm2090.

Kouthouridis, S.; Sotra, A.; Khan, Z.; Alvarado, J.; Raha, S.; Zhang, B. Modeling the Progression of Placental Transport from Early- to Late-Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization. Advanced Healthcare Materials 2023, 12 (32).

Zhang, F.; Lin, D. S. Y.; Rajasekar, S.; Sotra, A.; Zhang, B. Pump‐Less Platform Enables Long‐Term Recirculating Perfusion of 3D Printed Tubular Tissues. Advanced Healthcare Materials 2023, 12 (27).

Sotra, A.; Jozani, K. A.; Zhang, B. A vascularized crypt-patterned colon model for high-throughput drug screening and disease modelling. Lab on a Chip 2023, 23 (15), 3370-3387.

Kouthouridis, S.; Robson, E.; Hartung, A.; Raha, S.; Zhang, B. Se(XY) matters: the importance of incorporating sex in microphysiological models. Trends in Biotechnology 2022, 40 (11).

Deering, J.; Lin, D. S. Y.; D’Elia, A.; Zhang, B.; Grandfield, K. Fabrication of succinate-alginate xerogel films for in vitro coupling of osteogenesis and neovascularization. Biomaterials Advances 2022, 141, 213122.

Wang, Y.; Singer, R.; Liu, X.; Inman, S. J.; Cao, Q.; Zhou, Q.; Noble, A.; Li, L.; Arizpe, V.; Babi, M.; Ask, K.; Kolb, M.; Ramsay, S.; Geng, F.; Zhang, B.; Shargall, Y.; Moran‐Mirabal, J. M.; Dabaghi, M.; Hirota, J. A.The CaT stretcher: An open-source system for delivering uniaxial strain to cells and tissues (CaT). Frontiers in Bioengineering and Biotechnology 2022, 10.

Abdul, L.; Xu, J.; Sotra, A.; Chaudary, A.; Gao, J.; Rajasekar, S.; Anvari, N.; Mahyar, H.; Zhang, B. D-CryptO: deep learning-based analysis of colon organoid morphology from brightfield images. Lab on a Chip 2022, 22 (21), 4118-4128.

Jozani, K. A.; Kouthouridis, S.; Hirota, J. A.; Zhang, B. Next‐generation preclinical models of lung development, physiology and disease. The Canadian Journal of Chemical Engineering 2022, 101 (1), 18-40.

Rajasekar, S.; Lin, D. S. Y.; Zhang, F.; Sotra, A.; Boshart, A.; Clotet-Freixas, S.; Liu, A.; Hirota, J. A.; Ogawa, S.; Konvalinka, A.; Zhang, B. Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates. Lab on a Chip 2022, 22 (10), 1929-1942.

Sotra, A.; Zhang, B. Seeding a growing organ. Trends in Biotechnology 2021, 39 (8), 753-754.

Dabaghi, M.; Saraei, N.; Carpio, M. B.; Nanduri, V.; Ungureanu, J.; Babi, M.; Chandiramohan, A.; Noble, A.; Revill, S. D.; Zhang, B.; Ask, K.; Kolb, M.; Shargall, Y.; Moran-Mirabal, J.; Hirota, J. A. A robust protocol for decellularized human lung bioink generation amenable to 2D and 3D lung cell culture. Cells 2021, 10 (6), 1538.

Lai, B. F. L.; Lu, R. X. Z.; Huyer, L. D.; Kakinoki, S.; Yazbeck, J.; Wang, E. Y.; Wu, Q.; Zhang, B.; Radisic, M. A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nature Protocols 2021, 16 (4), 2158-2189.

Portillo-Esquivel, L. E.; Zhang, B. Application of cell, tissue, and biomaterial delivery in cardiac regenerative therapy. ACS Biomaterials Science & Engineering 2021, 7 (3), 1000-1021.

Abdul, L.; Rajasekar, S.; Lin, D. S. Y.; Raja, S. V.; Sotra, A.; Feng, Y.; Liu, A.; Zhang, B. Deep-LUMEN assay – human lung epithelial spheroid classification from brightfield images using deep learning. Lab on a Chip 2020, 21 (2), 447-448.

Hayward, K. L.; Kouthouridis, S.; Zhang, B. Organ-on-a-Chip Systems for Modeling Pathological Tissue Morphogenesis Associated with Fibrosis and Cancer. ACS Biomaterials Science & Engineering 2020, 7 (7), 2900-2925.

Rajasekar, S.; Lin, D. S. Y.; Abdul, L.; Liu, A.; Sotra, A.; Zhang, F.; Zhang, B. IFlowPlate—A customized 384‐Well plate for the culture of perfusable vascularized colon organoids. Advanced Materials 2020, 32 (46).

Lin, D. S. Y.; Rajasekar, S.; Marway, M. K.; Zhang, B. From model system to therapy: Scalable production of perfusable vascularized liver spheroids in “Open-Top“ 384-Well plate. ACS Biomaterials Science & Engineering 2020, 7 (7), 2964-2972.

Portillo‐Esquivel, L. E.; Nanduri, V.; Zhang, F.; Liang, W.; Zhang, B. z‐Wire: a microscaffold that supports guided tissue assembly and intramyocardium delivery for cardiac repair. Advanced Healthcare Materials 2020, 9 (14), e2000358.

Xie, R.; Korolj, A.; Liu, C.; Song, X.; Lu, R. X. Z.; Zhang, B.; Ramachandran, A.; Liang, Q.; Radisic, M. h-FIBER: microfluidic topographical hollow fiber for studies of glomerular filtration barrier. ACS Central Science 2020, 6 (6), 903-912.

Parrish, J.; Lim, K.; Zhang, B.; Radisic, M.; Woodfield, T. B. F. New frontiers for biofabrication and bioreactor design in microphysiological system development. Trends in Biotechnology 2019, 37 (12), 1327-1343.

Zhang, B.; Radisic, M. Organ-level vascularization: The Mars mission of bioengineering. Journal of Thoracic and Cardiovascular Surgery 2019, 159 (5), 2003-2007.

Zhao, Y.; Wang, E. Y.; Davenport, L. H.; Liao, Y.; Yeager, K.; Vunjak‐Novakovic, G.; Radisic, M.; Zhang, B. A multimaterial microphysiological platform enabled by rapid casting of elastic microwires. Advanced Healthcare Materials 2019, 8 (5), e1801187.

Zhao, Y.; Rafatian, N.; Feric, N. T.; Cox, B. J.; Aschar-Sobbi, R.; Wang, E. Y.; Aggarwal, P.; Zhang, B.; Conant, G.; Ronaldson-Bouchard, K.; Pahnke, A.; Protze, S.; Lee, J. H.; Huyer, L. D.; Jekic, D.; Wickeler, A.; Naguib, H. E.; Keller, G. M.; Vunjak-Novakovic, G.; Broeckel, U.; Backx, P. H.; Radisic, M. A platform for generation of Chamber-Specific cardiac tissues and disease modeling. Cell 2019, 176 (4), 913-927.e18.

Lin, D. S. Y.; Guo, F.; Zhang, B. Modeling organ-specific vasculature with organ-on-a-chip devices. Nanotechnology 2018, 30 (2), 024002.

Feric, N.; Aschar-Sobbi, R.; Zhao, Y.; Zhang, B.; Ronaldson, K.; Pallotta, I.; Vunjak-Novakovic, G.; Radisic, M. BiowireTM II matured human engineered 3D cardiac tissue for drug discovery and cardiotoxicity applications. Journal of Pharmacological and Toxicological Methods 2018, 93, 124.

Korolj, A.; Laschinger, C.; James, C.; Hu, E.; Velikonja, C.; Smith, N.; Gu, I.; Ahadian, S.; Willette, R.; Radisic, M.; Zhang, B. Curvature facilitates podocyte culture in a biomimetic platform. Lab on a Chip 2018, 18 (20), 3112-3128.

Zhang, B.; Lai, B. F. L.; Xie, R.; Huyer, L. D.; Montgomery, M.; Radisic, M. Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature. Nature Protocols 2018, 13 (8), 1793-1813.

Zhang, B.; Korolj, A.; Lai, B. F. L.; Radisic, M. Advances in organ-on-a-chip engineering. Nature Reviews Materials 2018, 3 (8), 257-278.

Ronaldson, K.; Feric, N.; Zhao, Y.; Zhang, B.; Conant, G.; Panhke, A.; Aschar-Sobbi, R.; Vunjak-Novakovic, G.; Backx, P.; Radisic, M. TARA Biosystems’ BioWireTM II: Engineering Mature human cardiac tissues enables more predictive drug screening. Journal of Pharmacological and Toxicological Methods 2017, 88, 242.

Ahadian, S.; Civitarese, R.; Bannerman, D.; Mohammadi, M. H.; Lu, R.; Wang, E.; Davenport‐Huyer, L.; Lai, B.; Zhang, B.; Zhao, Y.; Mandla, S.; Korolj, A.; Radisic, M. Organ‐On‐A‐Chip platforms: a convergence of advanced materials, cells, and microscale technologies. Advanced Healthcare Materials 2017, 7 (2).

Lai, B. F. L.; Huyer, L. D.; Lu, R. X. Z.; Drecun, S.; Radisic, M.; Zhang, B. InVADE: Integrated vasculature for assessing dynamic events. Advanced Functional Materials 2017, 27 (46).

Takebe, T.; Zhang, B.; Radisic, M. Synergistic Engineering: Organoids meet Organs-on-a-Chip. Cell Stem Cell 2017, 21 (3), 297-300.

Zhang, B.; Radisic, M. Organ-on-a-chip devices advance to market. Lab on a Chip 2017, 17 (14), 2395-2420.

Massé, S.; Magtibay, K.; Jackson, N.; Asta, J.; Kusha, M.; Zhang, B.; Balachandran, R.; Radisic, M.; Deno, D. C.; Nanthakumar, K. Resolving myocardial activation with novel omnipolar electrograms. Circulation – Arrhythmia and Electrophysiology 2016, 9 (7), e004107.

Huyer, L. D.; Zhang, B.; Korolj, A.; Montgomery, M.; Drecun, S.; Conant, G.; Zhao, Y.; Reis, L.; Radisic, M. Highly elastic and moldable polyester biomaterial for cardiac tissue engineering applications. ACS Biomaterials Science & Engineering 2016, 2 (5), 780-788.

Zhang, B.; Montgomery, M.; Chamberlain, M. D.; Ogawa, S.; Korolj, A.; Pahnke, A.; Wells, L. A.; Massé, S.; Kim, J.; Reis, L.; Momen, A.; Nunes, S. S.; Wheeler, A. R.; Nanthakumar, K.; Keller, G.; Sefton, M. V.; Radisic, M. Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis. Nature Materials 2016, 15 (6), 669-678.